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Prednisolone EP Impurity B Hydrochloride

SZ CAT No SZ-P027052
CAS No 906334-65-4
Mol.F. C21H26O5 : HCl
Mol.Wt. 358.4 : 36.5
Inv. Status Custom Synthesis
Rel. CAS No 53-03-2 (free base)


Chemical Name: 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione Hydrochloride (as per EP)

Smiles: C[C@@]1(C2)[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3([H])C2=O)=O.Cl

Inchi: InChI=1S/C21H30O5.ClH/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19;/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3;1H/t14-,15-,16-,18+,19-,20-,21-;/m0./s1

Validated stability indicating RP-​LC assay for determination of gatifloxacin and prednisolone acetatein ophthalmic preparations and biological samples
By Qadir, Muhammad A.; Shahzad, Shabnam; Ahmed, Mahmood; Razzaq, Syed S.; Shafiq, Muhmmad I.
From Latin American Journal of Pharmacy (2016), 35(5), 912-920
 
Novel stability indicating RP-​HPLC method for the simultaneous estimation of moxifloxacin and prednisolone in bulk and their combined dosage form
By Potnuri, Naga Raju; Rao, G. Devala; Prasad, Y. Rajendra
From International Journal of Pharmaceutical Sciences and Research (2015), 6(5), 1965-1973
 
Development and validation of a new stability indicating reversed phase liquid chromatographic method for the determination of prednisolone acetate and impurities in an ophthalmic suspension
By Marley, Adrian; Stalcup, Apryll M.; Connolly, Damian
From Journal of Pharmaceutical and Biomedical Analysis (2015), 102, 261-266