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Posaconazole Nitrosamine Impurity 1

SZ CAT No SZ-P022115
CAS No NA
Mol.F. C24H26F2N6O3
Mol.Wt. 484.5
Inv. Status Custom Synthesis


Chemical Name: 1-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)-4-nitrosopiperazine

Smiles: O=NN1CCN(C2=CC=C(OC[C@@H]3CO[C@](C4=CC=C(F)C=C4F)(CN5N=CN=C5)C3)C=C2)CC1

Inchi: InChI=1S/C17H24N6O3/c1-3-16(13(2)24)23-17(25)22(12-18-23)15-6-4-14(5-7-15)20-8-10-21(19-26)11-9-20/h4-7,12-13,16,24H,3,8-11H2,1-2H3/t13-,16-/m0/s1

Influence of cyclodextrin on posaconazole stability, release and activity: Improve the utility of the drug
By Santana, Ana Cristina Sousa Gramoza Vilarinho; Nadvorny, Daniela; da Rocha Passos, Taisa Daiany; de La Roca Soares, Monica Felts; Soares-Sobrinho, Jose Lamartine
From Journal of Drug Delivery Science and Technology (2019), 53, 101153
 
Stability-​indicating HPLC method development and structural elucidation of novel degradation products in posaconazole injection by LC-​TOF​/MS, LC-​MS​/MS and NMR
By Yang, Yidi; Zhu, Xi; Zhang, Fei; Li, Wei; Wu, Ying; Ding, Li
From Journal of Pharmaceutical and Biomedical Analysis (2016), 125, 165-177
 
Stability indicating HPLC method for the quantification of posaconazole and its related substances
By Govind, Sampath Kumar Reddy; Nagaraju, Ch. V. S.; Rajan, S. T.; Eshwaraiah, S.; Kishore, M.; Rakesh, M.; Chakravarthy, I. E.
From Pharma Chemica (2014), 6(1), 486-494, 9 pp..