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Posaconazole Impurity 22

SZ CAT No SZ-P022042
CAS No 1388148-30-8
Mol.F. C36H40F2N8O4 
Mol.Wt. 686.8
Inv. Status Custom Synthesis

Chemical Name: D-​threo-​Pentitol, 2,​5-​anhydro-​1,​3,​4-​trideoxy-​2-​C-​(2,​4-​difluorophenyl)​-​4-​[[[4-​[4-​[1-​[(1S,​2S)​-​1-​ethyl-​2-​hydroxypropyl]​-​1,​5-​dihydro-​5-​oxo-​4H-​1,​2,​4-​triazol-​4-​yl]​phenyl]​-​2,​3,​4,​5-​tetrahydro-​1H-​1,​4-​benzodiazepin-​7-​yl]​oxy]​methyl]​-​1-​(1H-​1,​2,​4-​triazol-​1-​yl)​-;

Smiles: O=C(N([C@@H](CC)[C@@H](O)C)N=C1)N1C2=CC=C(N3CCNC4=CC=C(OC[C@H]5O[C@@](C6=C(F)C=C(F)C=C6)(CN7C=NC=N7)OC5)C=C4C3)C=C2

Influence of cyclodextrin on posaconazole stability, release and activity: Improve the utility of the drug
By Santana, Ana Cristina Sousa Gramoza Vilarinho; Nadvorny, Daniela; da Rocha Passos, Taisa Daiany; de La Roca Soares, Monica Felts; Soares-Sobrinho, Jose Lamartine
From Journal of Drug Delivery Science and Technology (2019), 53, 101153
Stability-​indicating HPLC method development and structural elucidation of novel degradation products in posaconazole injection by LC-​TOF​/MS, LC-​MS​/MS and NMR
By Yang, Yidi; Zhu, Xi; Zhang, Fei; Li, Wei; Wu, Ying; Ding, Li
From Journal of Pharmaceutical and Biomedical Analysis (2016), 125, 165-177
Stability indicating HPLC method for the quantification of posaconazole and its related substances
By Govind, Sampath Kumar Reddy; Nagaraju, Ch. V. S.; Rajan, S. T.; Eshwaraiah, S.; Kishore, M.; Rakesh, M.; Chakravarthy, I. E.
From Pharma Chemica (2014), 6(1), 486-494, 9 pp..