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Posaconazole 3-OXO impurity

SZ CAT No SZ-P022067
CAS No 357189-94-7
Mol.F. C37H40F2N8O5
Mol.Wt. 714.8
Inv. Status Under Synthesis


Chemical Name: 4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)-1-(4-(1-((2S,3S)-2-hydroxypentan-3-yl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)phenyl)piperazin-2-one

Smiles: FC1=C(C=CC(F)=C1)[C@]2(C[C@H](COC3=CC=C(N(CCN4C5=CC=C(N(C=NN6[C@@H](CC)[C@@H](O)C)C6=O)C=C5)CC4=O)C=C3)CO2)CN7C=NC=N7

Inchi: InChI=1/C7H13Br/c1-5(2)7(8)6-3-4-6/h5-7H,3-4H2,1-2H3

Influence of cyclodextrin on posaconazole stability, release and activity: Improve the utility of the drug
By Santana, Ana Cristina Sousa Gramoza Vilarinho; Nadvorny, Daniela; da Rocha Passos, Taisa Daiany; de La Roca Soares, Monica Felts; Soares-Sobrinho, Jose Lamartine
From Journal of Drug Delivery Science and Technology (2019), 53, 101153
 
Stability-​indicating HPLC method development and structural elucidation of novel degradation products in posaconazole injection by LC-​TOF​/MS, LC-​MS​/MS and NMR
By Yang, Yidi; Zhu, Xi; Zhang, Fei; Li, Wei; Wu, Ying; Ding, Li
From Journal of Pharmaceutical and Biomedical Analysis (2016), 125, 165-177
 
Stability indicating HPLC method for the quantification of posaconazole and its related substances
By Govind, Sampath Kumar Reddy; Nagaraju, Ch. V. S.; Rajan, S. T.; Eshwaraiah, S.; Kishore, M.; Rakesh, M.; Chakravarthy, I. E.
From Pharma Chemica (2014), 6(1), 486-494, 9 pp..