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Pemetrexed EP Impurity A Sodium Salt

SZ CAT No SZ-P014030
CAS No 2243918-27-4
Mol.F. C21H23N5O6 : Na
Mol.Wt. 441.4 : 23.0
Inv. Status Custom Synthesis
Rel. CAS No 869791-42-4 (free base)


Chemical Name: (2S)-2-[4-[2-(2-Amino-1-methyl-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzamido]pentanedioic acid Sodium salt (as per EP); {4-[2-(2-Amino-1-methyl-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-l-glutamic acid Sodium salt (as per USP)

Synonym: Pemetrexed USP impurity a ; N-Methyl Pemetrexed Impurity

Development of a purity control strategy for pemetrexed disodium and validation of associated analytical methodology
Anne Warner ∗, Irina Piraner, Heather Weimer, Kevin White
Journal of Pharmaceutical and Biomedical Analysis 105 (2015) 46–54
 
RP-HPLC Method Validation for Quantitative Analysis of Pemetrexed Disodium Hemipentahydrate
Vitthal M. Dhalape, Santosh T. Khadangale, Rahul V. Pinjari
Research Journal of Pharmacy and Technology 2020; 13(8):3685-3689.