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N-Desmethyl Sorafenib Tosylate

SZ CAT No SZ-S012013
CAS No 943024-27-9
Mol.F. C20H14ClF3N4O3 : C7H8O3S
Mol.Wt. 450.8 : 172.2
Inv. Status Custom Synthesis
Rel. CAS No 284461-74-1 (free base)

Chemical Name: 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinamide Tosylate

Smiles: NC(C1=CC(OC2=CC=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2)=CC=N1)=O.O=[S](O)(C4=CC=C(C)C=C4)=O

Inchi: InChI=1S/C13H13N3O2.ClH/c1-15-13(17)12-8-11(6-7-16-12)18-10-4-2-9(14)3-5-10;/h2-8H,14H2,1H3,(H,15,17);1H

Fragmentation pathways and differentiation of positional isomers of sorafenib and structural analogues by ESI-IT-MSn and ESI-Q-TOF-MS/MS coupled with DFT calculations
By Yu, Dandan; Liang, Xianrui
From Journal of Mass Spectrometry (2018), 53(7), 579-589.
Box-Behnken design based statistical modelling for optimization of U PLC-MS/MS method for analysis of sorafenib in bulk and tablets
By Wanii, Tanveer A.; Alanazi, Amer M.; Zargar, Seema; Ahmad, Ajaz; Drawish, Ibrahim A.
From Journal of Computational and Theoretical Nanoscience (2015), 12(10), 3598-3604

Determination of sorafenib in human plasma by HPLC
By Liu, Weifeng; Cao, Pengjian; Zhang, Chunfang; Xia, Dongxia; Che, Shujuan; Lou, Dan; Qiu, Xiangjun
From Zhongguo Xiandai Yingyong Yaoxue (2015), 32(2), 182-185