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Erythromycin EP Impurity B

SZ CAT No SZ-E006005
CAS No 992-62-1
Mol.F. C36H65NO13
Mol.Wt. 719.9
Inv. Status Custom Synthesis


Chemical Name: (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(methylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione (as per EP); (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-Ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-6-{[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (as per USP)

Synonym: Erythromycin USP Related Compound N ; 3″-N-Desmethylerythromycin A ; N-Demethylerythromycin A

Smiles: C[C@@H]([C@@H]([C@H](C(O[C@@H]1CC)=O)C)O[C@@](O[C@@H](C)[C@@H]2O)([H])C[C@@]2(C)OC)[C@H]([C@](O)(C[C@H](C([C@@H]([C@@H](O)[C@@]1(O)C)C)=O)C)C)O[C@@](O[C@H](C)C[C@@H]3NC)([H])[C@@H]3O

Inchi: InChI=1S/C20H21N3O/c24-14-8-7-13-21-18-15-22-19(16-9-3-1-4-10-16)20(23-18)17-11-5-2-6-12-17/h1-6,9-12,15,24H,7-8,13-14H2,(H,21,23)

Isolation and identification of a novel erythromycin-​degrading fungus, Curvularia sp. RJJ-​5, and its degradation pathway
By Ren, Jianjun; Deng, Liujie; Niu, Dongze; Wang, Zhenzhu; Fan, Bo; Taoli, Huhe; Li, Zhijie; Zhang, Jin; Li, Chunyu
From FEMS Microbiology Letters (2021), 368(1), fnaa215.
 
Development and validation of a stability indicating HPLC method for organic impurities of erythromycin stearate tablets
By Jeelani, Salika; Soukhova, Nadejda
From Journal of Pharmaceutical and Biomedical Analysis (2021), 195, 113858
 
Degradation and mineralization of erythromycin by heterogeneous photocatalysis using SnO2-​doped TiO2 structured catalysts: Activity and stability
By Albornoz, L. L.; da Silva, S. W.; Bortolozzi, J. P.; Banus, E. D.; Brussino, P.; Ulla, M. A.; Bernardes, A. M.
From Chemosphere (2021), 268, 128858