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Decitabine Ring-Opening Impurity

SZ CAT No SZ-D019016
CAS No 69304-64-9
Mol.F. C8H14N4O5
Mol.Wt. 246.2
Inv. Status Under Synthesis

Chemical Name: N-((Z)-N'-(((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)carbamoyl)carbamimidoyl)formamide

Smiles: OC[C@@H]1[C@@H](O)C[C@H](NC(/N=C(N)\NC([H])=O)=O)O1

Inchi: InChI=1S/C7H14N4O4/c8-6(9)11-7(14)10-5-1-3(13)4(2-12)15-5/h3-5,12-13H,1-2H2,(H5,8,9,10,11,14)/t3-,4+,5?/m0/s1

Development, validation, and clinical application of a high-performance liquid chromatography-tandem mass spectrometry assay for the quantifica0074ion of total intracellular -decitabine nucleotides and genomic DNA incorporated -decitabine and 5-methyl-2 -deoxycytidine
Jeroen Roosendaal , Hilde Rosinga, Luc Lucas a, Aram Oganesianc, Jan H.M. Schellens b,d,e, Jos H. Beijnen
Journal of Pharmaceutical and Biomedical Analysis 164 (2019) 16–26
Isolation, characterization, and properties of a labile hydrolysis product of the antitumor nucleoside, 5-azacytidine
John A. Beisler
J. Med. Chem. 1978, 21, 2, 204–208
Stability indicating RP-HPLC Method Devlopment and Validation of Decitabine Drug in Formulation
Glory hepsiba1 *, Dr.B.B.Teja2 , K.Ashok kumar1 , Y.Ravindra reddy
International Journal of PharmTech Research CODEN (USA): IJPRIF Vol. 3, No.1, pp 237-243,