Chemical Name: (11Beta,21-Dihydroxypregna-1,4,16-triene-3,20-dione) (as per USP)
Synonym: Desonide 16-Ene Impurity
Smiles: O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC=C4C(CO)=O)=C1
Inchi: InChI=1S/C24H30O5/c1-21(2)28-20-12-18-16-6-5-14-11-15(26)7-9-22(14,3)17(16)8-10-23(18,4)24(20,29-21)19(27)13-25/h7-9,11,16,18,20,25H,5-6,10,12-13H2,1-4H3/t16?,18?,20-,22-,23-,24+/m0/s1
Development of a novel HPLC method for the determination of the impurities in desonide cream and characterization of its impurities by 2D LC-IT-TOF MS
Jian Wanga,b, Shuxian Zhenga, Yu Xua, Haiyan Huc, Minji Shenc, Lan Tang
Journal of Pharmaceutical and Biomedical Analysis 161 (2018) 399–406
Studies on the Stability of Corticosteroids: Degradation of Clobetasol Propionate, Desonide and Hydrocortisone in Topical Formulations by HPLC and UPLC-MS/MS
Kishore Kumar Hotha, Subathra Ramamoorthy1, Hiren Patel
American Journal of Analytical Chemistry, 2020, 11, 147-171