Chemical Name: 4-[(1Ξ)-2-(tert-butylamino)-1-hydroxyethyl]-2-[[5-[(1Ξ)-2-(tert-butylamino)-1-hydroxyethyl]-2-hydroxyphenyl]methyl]-6-(hydroxymethyl)phenol (as per EP)
Synonym: Salbutamol BP Impurity N ; Albuterol Dimer
Smiles: OCC1=C(O)C(CC2=CC(C(O)CNC(C)(C)C)=CC=C2O)=CC(C(O)CNC(C)(C)C)=C1
Inchi: InChI=1/C14H23NO3/c1-14(2,3)15-8-13(17)10-5-6-12(16)11(7-10)9-18-4/h5-7,13,15-17H,8-9H2,1-4H3
Quantitative determination of salbutamol sulfate impurities using achiral supercritical fluid chromatography
AmandineDispasaVincentDesfontainebBertylAndriaPierreLebrunacDorinaKotonidAdrianClarkedDavyGuillarmebPhilippeHuberta
Journal of Pharmaceutical and Biomedical Analysis
Volume 134, 5 February 2017, Pages 170-180
Evolved gas analysis during thermal degradation of salbutamol sulphate
Fabio Sonvico, Victoria Coleman, Daniela Traini & Paul M. Young
Journal of Thermal Analysis and Calorimetry volume 120, pages789–794 (2015)
A chromatography-free synthesis of racemic salbutamol hemisulfate
AgatheVanoostLaurentPetit
Tetrahedron Letters
Volume 61, Issue 28, 9 July 2020, 152126