Chemical Name: (2R)-2-[4-[2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzamido]pentanedioic acid (as per EP)
Synonym: Pemetrexed R-Isomer
Smiles: O=C(O)[C@H](NC(C1=CC=C(CCC2=CNC(NC(N)=N3)=C2C3=O)C=C1)=O)CCC(O)=O
Inchi: InChI=1S/C24H21ClFN3O5/c1-24(26)19(34-21(31)16-10-6-3-7-11-16)17(14-25)33-22(24)29-13-12-18(28-23(29)32)27-20(30)15-8-4-2-5-9-15/h2-13,17,19,22H,14H2,1H3,(H,27,28,30,32)/t17-,19-,22-,24-/m1/s1
A stability-indicating LC-MS/MS method optimization for Pemetrexed through design of experiments: Identification and characterization of major oxidative degradation product
By Narenderan, S. T.; Ramesh, J.; Babu, B.; Meyyanathan, S. N.
From Journal of Pharmaceutical and Biomedical Analysis (2020), 183, 113150
A new validated stability-indicating gradient RP-HPLC method for the determination of pemetrexed disodium and its process related substances
By Hemchand, S.; Babu, R. Ravi Chandra; Annapurna, Mukthinuthalapati Mathrusri
From Journal of Drug Delivery and Therapeutics (2019), 9(3Suppl.), 588-610
Content determination of related impurity-L-isomer in Pemetrexed Disodium for injection by HPLC
By Li, Jinhua; Yang, Mei
From Heilongjiang Yiyao (2014), 27(3), 498-500