Chemical Name: 2-((6-Amino-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)oxy)ethan-1-ol
Smiles: OCCOC1=NC(C2=NC=CC=N2)=NC(N)=C1OC3=C(OC)C=CC=C3
Inchi: InChI=1S/C15H13N5O3/c1-22-9-5-2-3-6-10(9)23-11-12(16)19-14(20-15(11)21)13-17-7-4-8-18-13/h2-8H,1H3,(H3,16,19,20,21)
Research and Development of a Second-Generation Process for Bosentan, an Endothelin Receptor Antagonist
Peter J. Harrington, Hiralal N. Khatri, Brad S. DeHoff, Martin R. Guinn, Mark A. Boehler, and Karl A. Glaser
Organic Process Research & Development 2002, 6, 120−124
Stability-Indicating Gradient RP-LC Method for the Determination of Process and Degradation Impurities in Bosentan Monohydrate: An Endothelin Receptor Antagonist
Sanjay A. Jadhav,1 Shashikant B. Landge,1 Sonali L. Jadhav,1 Navanath C. Niphade,1 Saroj R. Bembalkar,2 and Vijayavitthal T. Mathad1
E-Hindawi Access to Research Chromatography Research International Volume 2011, Article ID 929876, 9 pages
Development and validation of a stability indicating analytical method for the related substances of Bosentan drug substance by HPLC
Mubeen Ahmad Khan, Sukumar Sinha, Mangesh Todkar, Vikas Parashar, K. Swamy Reddy
Am. J. Sci. Ind. Res., 2012, 3(2): 69-80