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Bortezomib Intermediate(S,R)

SZ CAT No SZ-B004052
CAS No 84110-34-9
Mol.F. C14H25BO2
Mol.Wt. 236.2
Inv. Status Custom Synthesis


Chemical Name: (3aS,7aR)-2-isobutyl-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborole

Analysis of Two Commercially Available Bortezomib Products: Differences in Assay of Active Agent and Impurity Profile
Stephen R. Byrn, Patrick A. Tishmack, Mark J. Milton & Helgi van de Velde
AAPS PharmSciTech volume 12, pages461–467(2011)
 
Isolation, Solubility, and Characterization of D-Mannitol Esters of 4-Methoxybenzeneboronic Acid
Antonio Lopalco 1 , William A. Marinaro 1 , Victor W. Day 2 , Valentino J. Stella
J Pharm Sci. 2017 Feb;106(2):601-610
 
Oxidative Deboronation of the Peptide Boronic Acid Proteasome Inhibitor Bortezomib: Contributions from Reactive Oxygen Species in This Novel Cytochrome P450 Reaction
Jason Labutti,† Ian Parsons,‡ Ron Huang, Gerald Miwa, Liang-Shang Gan, and J. Scott Daniels
Chem. Res. Toxicol. 2006, 19, 539-546