Chemical Name: Methyl 2-(2-((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl) morpholino)-1-iminoethyl)hydrazinecarboxylate ;
Smiles: N=C(NNC(OC)=O)CN1[C@@H](C2=CC=C(F)C=C2)[C@@H](O[C@@H](C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)OCC1
Inchi: InChI=1S/C23H21F7N4O4/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)38-20-19(13-2-4-17(24)5-3-13)34(36,6-7-37-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-,34?/m1/s1
Application of analytical quality by design principles for the determination of alkyl p-toluenesulfonates impurities in Aprepitant by HPLC. Validation using total-error concept
Constantinos K. Zacharis, Elli Vastardi
Journal of Pharmaceutical and Biomedical Analysis Volume 150, 20 February 2018, Pages 152-161
Characterization and Quantitation of Aprepitant Drug Substance Polymorphs by Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy
Roy Helmy,* George X. Zhou, Yadan W. Chen, Louis Crocker, Tao Wang, Robert M. Wenslow, Jr., and Anant Vailaya*
Anal. Chem. 2003, 75, 605-611
Development and Optimization of Liquid Chromatography Analytical Methods by Using AQbD Principles: Overview and Recent Advances
Tim Tome,†,Nina Ž igart, Zdenko Č asar,, and AlešObreza
Org. Process Res. Dev. 2019, 23, 1784−1802