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Aprepitant M2 Metabolite (1R, 2R, 3R)-Isomer

SZ CAT No SZ-A030012
CAS No 380499-06-9
Mol.F. C20H18F7NO2 
Mol.Wt. 437.4
Inv. Status Custom Synthesis
Rel. CAS No 1447693-83-5 (HCl) ; 1447614-53-0 (Sulfate)

Chemical Name: (2R,3R)-2-((1R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluoro phenyl) morpholine

Synonym: Aprepitant M2 metabolite (1R, 2R, 3R)-isomer ; Aprepitant M2 Metabolite 3-Epimer

Application of analytical quality by design principles for the determination of alkyl p-toluenesulfonates impurities in Aprepitant by HPLC. Validation using total-error concept
Constantinos K. Zacharis, Elli Vastardi
Journal of Pharmaceutical and Biomedical Analysis Volume 150, 20 February 2018, Pages 152-161
Characterization and Quantitation of Aprepitant Drug Substance Polymorphs by Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy
Roy Helmy,* George X. Zhou, Yadan W. Chen, Louis Crocker, Tao Wang, Robert M. Wenslow, Jr., and Anant Vailaya*
Anal. Chem. 2003, 75, 605-611
Development and Optimization of Liquid Chromatography Analytical Methods by Using AQbD Principles: Overview and Recent Advances
Tim Tome,†,Nina Ž igart, Zdenko Č asar,, and AlešObreza
Org. Process Res. Dev. 2019, 23, 1784−1802