Chemical Name: (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine
Smiles: COC1=C(OCC)C=C([C@H](N)CS(C)(=O)=O)C=C1
Inchi: InChI=1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3
Identification and characterization of process-related substances and degradation products in apremilast: process optimization and degradation pathway elucidation
Yuting Lu, Xiaoyue Shen, Taijun Hang, Min Song
J Pharm Biomed Anal. 2017 Jul 15;141:70-78
Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-r Inhibitor
Hon-Wah Man, Peter Schafer, Lu Min Wong, Rebecca T. Patterson, Laura G. Corral, Heather Raymon, Kate Blease, Jim Leisten, Michael A. Shirley, Yang Tang, Darius M. Babusis, Roger Chen, Dave Stirling, and George W. Muller
J. Med. Chem. 2009, 52, 1522–1524
Identification, characterization and HPLC quantification for impurities of Apremilast
Kaihe Xionga , Xingling Mab , Na Caob ,Lei Liub ,Lili Suna , Qiaogen Zoub , Ping Wei
Analytical Methods 8(8)
Design of experiment avenue for development and validation of RP-HPLC-PDA method for determination of apremilast in bulk and in in-house tablet formulation
Suraj R. Chaudhari* and Atul A. Shirkhedkar
Journal of Analytical Science and Technology volume 10, Article number: 10 (2019)