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Pharmaceutical Reference Standards

Afatinib

Picture of Afatinib
CAT No: SZ-A054001
CAS No: 850140-72-6
Mol.F. : C24H25ClFN5O3
Mol.Wt. : 485.9
Inv. Status: In Stock
Rel. CAS No : 1398312-49-6 (HCl salt) ; 1398312-36-1 (Sulfate salt) ; 850140-73-7 (Dimaleat salt)
SZ-A054001
CAS No:850140-72-6
Mol.F.: C24H25ClFN5O3
Mol.Wt.: 485.9
Inv. Status: In Stock
Rel. CAS No : 1398312-49-6 (HCl salt) ; 1398312-36-1 (Sulfate salt) ; 850140-73-7 (Dimaleat salt)

Afatinib Impurity A

Picture of Afatinib Impurity A
CAT No: SZ-A054002
CAS No: 402855-07-6
Mol.F. : C18H14ClFN4O4
Mol.Wt. : 404.8
Inv. Status: In Stock
SZ-A054002
CAS No:402855-07-6
Mol.F.: C18H14ClFN4O4 
Mol.Wt.: 404.8
Inv. Status: In Stock

Afatinib Impurity B

Picture of Afatinib Impurity B
CAT No: SZ-A054003
CAS No: 314771-76-1
Mol.F. : C18H16ClFN4O2
Mol.Wt. : 374.8
Inv. Status: In Stock
Rel. CAS No : 2047333-82-2 (HCl salt)
SZ-A054003
CAS No:314771-76-1
Mol.F.: C18H16ClFN4O2 
Mol.Wt.: 374.8
Inv. Status: In Stock
Rel. CAS No : 2047333-82-2 (HCl salt)

Afatinib Impurity C

Picture of Afatinib Impurity C
CAT No: SZ-A054004
CAS No: 945553-91-3
Mol.F. : C24H25ClFN5O3
Mol.Wt. : 486.0
Inv. Status: In Stock
SZ-A054004
CAS No:945553-91-3
Mol.F.: C24H25ClFN5O3 
Mol.Wt.: 486.0
Inv. Status: In Stock

Afatinib Impurity D

Picture of Afatinib Impurity D
CAT No: SZ-A054005
CAS No: 1680184-59-1
Mol.F. : C24H25ClFN5O3
Mol.Wt. : 485.9
Inv. Status: In Stock
SZ-A054005
CAS No:1680184-59-1
Mol.F.: C24H25ClFN5O3
Mol.Wt.: 485.9
Inv. Status: In Stock

Afatinib Impurity E

Picture of Afatinib Impurity E
CAT No: SZ-A054006
CAS No: NA
Mol.F. : C24H25Cl2N5O3
Mol.Wt. : 502.4
Inv. Status: Custom Synthesis
SZ-A054006
CAS No:NA
Mol.F.: C24H25Cl2N5O3 
Mol.Wt.: 502.4
Inv. Status: Custom Synthesis

Afatinib Impurity F

Picture of Afatinib Impurity F
CAT No: SZ-A054007
CAS No: NA
Mol.F. : C24H25F2N5O3
Mol.Wt. : 469.5
Inv. Status: Custom Synthesis
SZ-A054007
CAS No:NA
Mol.F.: C24H25F2N5O3 
Mol.Wt.: 469.5
Inv. Status: Custom Synthesis

Afatinib Impurity G

Picture of Afatinib Impurity G
CAT No: SZ-A054008
CAS No: NA
Mol.F. : C24H25ClFN5O3
Mol.Wt. : 486.0
Inv. Status: Custom Synthesis
SZ-A054008
CAS No:NA
Mol.F.: C24H25ClFN5O3 
Mol.Wt.: 486.0
Inv. Status: Custom Synthesis

Afatinib Impurity I

Picture of Afatinib Impurity I
CAT No: SZ-A054010
CAS No: NA
Mol.F. : C22H19BrClFN4O3
Mol.Wt. : 521.8
Inv. Status: Custom Synthesis
SZ-A054010
CAS No:NA
Mol.F.: C22H19BrClFN4O3 
Mol.Wt.: 521.8
Inv. Status: Custom Synthesis

Afatinib Impurity J

Picture of Afatinib Impurity J
CAT No: SZ-A054011
CAS No: 1456696-14-2
Mol.F. : C18H22N4O4
Mol.Wt. : 358.4
Inv. Status: Custom Synthesis
SZ-A054011
CAS No:1456696-14-2
Mol.F.: C18H22N4O4
Mol.Wt.: 358.4
Inv. Status: Custom Synthesis

N-Desmethyl Afatinib

Picture of N-Desmethyl Afatinib
CAT No: SZ-A054012
CAS No: 2413212-13-0
Mol.F. : C23H23ClFN5O3
Mol.Wt. : 471.9
Inv. Status: Custom Synthesis
SZ-A054012
CAS No:2413212-13-0
Mol.F.: C23H23ClFN5O3
Mol.Wt.: 471.9
Inv. Status: Custom Synthesis

Afatinib N-Oxide

Picture of Afatinib N-Oxide
CAT No: SZ-A054013
CAS No: 2413212-11-8
Mol.F. : C24H25ClFN5O4
Mol.Wt. : 501.9
Inv. Status: Limited Stock
SZ-A054013
CAS No:2413212-11-8
Mol.F.: C24H25ClFN5O4
Mol.Wt.: 501.9
Inv. Status: Limited Stock

Afatinib Impurity 2

Picture of Afatinib Impurity 2
CAT No: SZ-A054014
CAS No: 1449430-45-8
Mol.F. : C14H8ClFN4O3
Mol.Wt. : 334.7
Inv. Status: Custom Synthesis
SZ-A054014
CAS No:1449430-45-8
Mol.F.: C14H8ClFN4O3 
Mol.Wt.: 334.7
Inv. Status: Custom Synthesis

Afatinib Impurity 3

Picture of Afatinib Impurity 3
CAT No: SZ-A054015
CAS No: 2475094-96-1
Mol.F. : C14H7ClF2N4O2
Mol.Wt. : 336.7
Inv. Status: Custom Synthesis
SZ-A054015
CAS No:2475094-96-1
Mol.F.: C14H7ClF2N4O2 
Mol.Wt.: 336.7
Inv. Status: Custom Synthesis

Afatinib Impurity 4

Picture of Afatinib Impurity 4
CAT No: SZ-A054016
CAS No: 2512206-82-3
Mol.F. : C14H7Cl2FN4O2
Mol.Wt. : 353.1
Inv. Status: Custom Synthesis
SZ-A054016
CAS No:2512206-82-3
Mol.F.: C14H7Cl2FN4O2 
Mol.Wt.: 353.1
Inv. Status: Custom Synthesis

Afatinib Impurity 5

Picture of Afatinib Impurity 5
CAT No: SZ-A054017
CAS No: 179552-74-0
Mol.F. : C15H10ClFN4O3
Mol.Wt. : 348.7
Inv. Status: Custom Synthesis
Rel. CAS No : 1012057-48-5 (HCl salt)
SZ-A054017
CAS No:179552-74-0
Mol.F.: C15H10ClFN4O3 
Mol.Wt.: 348.7
Inv. Status: Custom Synthesis
Rel. CAS No : 1012057-48-5 (HCl salt)

Afatinib Impurity 6

Picture of Afatinib Impurity 6
CAT No: SZ-A054018
CAS No: 2413212-07-2
Mol.F. : C18H17FN4O2
Mol.Wt. : 340.4
Inv. Status: Custom Synthesis
SZ-A054018
CAS No:2413212-07-2
Mol.F.: C18H17FN4O2 
Mol.Wt.: 340.4
Inv. Status: Custom Synthesis

Afatinib Impurity 7

Picture of Afatinib Impurity 7
CAT No: SZ-A054019
CAS No: 2413212-08-3
Mol.F. : C18H18N4O2
Mol.Wt. : 322.4
Inv. Status: Custom Synthesis
SZ-A054019
CAS No:2413212-08-3
Mol.F.: C18H18N4O2 
Mol.Wt.: 322.4
Inv. Status: Custom Synthesis

Afatinib Impurity 8

Picture of Afatinib Impurity 8
CAT No: SZ-A054020
CAS No: 2413212-09-4
Mol.F. : C18H17ClN4O2
Mol.Wt. : 356.8
Inv. Status: Custom Synthesis
SZ-A054020
CAS No:2413212-09-4
Mol.F.: C18H17ClN4O2 
Mol.Wt.: 356.8
Inv. Status: Custom Synthesis

Afatinib Impurity 9

Picture of Afatinib Impurity 9
CAT No: SZ-A054021
CAS No: 2413212-10-7
Mol.F. : C30H36ClFN6O5
Mol.Wt. : 615.1
Inv. Status: Custom Synthesis
SZ-A054021
CAS No:2413212-10-7
Mol.F.: C30H36ClFN6O5 
Mol.Wt.: 615.1
Inv. Status: Custom Synthesis

Afatinib Impurity 10

Picture of Afatinib Impurity 10
CAT No: SZ-A054022
CAS No: NA
Mol.F. : C48H50Cl2F2N10O6
Mol.Wt. : 971.9
Inv. Status: Custom Synthesis
SZ-A054022
CAS No:NA
Mol.F.: C48H50Cl2F2N10O6 
Mol.Wt.: 971.9
Inv. Status: Custom Synthesis

Afatinib Impurity 11

Picture of Afatinib Impurity 11
CAT No: SZ-A054023
CAS No: 2413212-17-4
Mol.F. : C22H20ClFN4O3
Mol.Wt. : 442.9
Inv. Status: Custom Synthesis
SZ-A054023
CAS No:2413212-17-4
Mol.F.: C22H20ClFN4O3 
Mol.Wt.: 442.9
Inv. Status: Custom Synthesis

Afatinib Impurity 12

Picture of Afatinib Impurity 12
CAT No: SZ-A054024
CAS No: 2121530-37-6
Mol.F. : C22H20ClFN4O4
Mol.Wt. : 458.9
Inv. Status: Custom Synthesis
SZ-A054024
CAS No:2121530-37-6
Mol.F.: C22H20ClFN4O4 
Mol.Wt.: 458.9
Inv. Status: Custom Synthesis

Afatinib Impurity 13

Picture of Afatinib Impurity 13
CAT No: SZ-A054025
CAS No: 2413212-19-6
Mol.F. : C22H20ClFN4O4
Mol.Wt. : 458.9
Inv. Status: In Stock
SZ-A054025
CAS No:2413212-19-6
Mol.F.: C22H20ClFN4O4 
Mol.Wt.: 458.9
Inv. Status: In Stock

Afatinib Impurity 14

Picture of Afatinib Impurity 14
CAT No: SZ-A054026
CAS No: 2413212-21-0
Mol.F. : C24H27ClFN5O4
Mol.Wt. : 504.0
Inv. Status: Under Synthesis
SZ-A054026
CAS No:2413212-21-0
Mol.F.: C24H27ClFN5O4 
Mol.Wt.: 504.0
Inv. Status: Under Synthesis

Afatinib Impurity 15

Picture of Afatinib Impurity 15
CAT No: SZ-A054027
CAS No: 2413212-23-2
Mol.F. : C24H27ClFN5O4
Mol.Wt. : 504.0
Inv. Status: Under Synthesis
SZ-A054027
CAS No:2413212-23-2
Mol.F.: C24H27ClFN5O4 
Mol.Wt.: 504.0
Inv. Status: Under Synthesis

Afatinib Impurity 16

Picture of Afatinib Impurity 16
CAT No: SZ-A054028
CAS No: 2223677-60-7
Mol.F. : C19H16ClFN4O3
Mol.Wt. : 402.8
Inv. Status: Under Synthesis
SZ-A054028
CAS No:2223677-60-7
Mol.F.: C19H16ClFN4O3
Mol.Wt.: 402.8
Inv. Status: Under Synthesis

Afatinib Impurity 17

Picture of Afatinib Impurity 17
CAT No: SZ-A054029
CAS No: NA
Mol.F. : C21H22ClFN5O2
Mol.Wt. : 430.9
Inv. Status: Custom Synthesis
SZ-A054029
CAS No:NA
Mol.F.: C21H22ClFN5O2 
Mol.Wt.: 430.9
Inv. Status: Custom Synthesis

Afatinib Impurity 18

Picture of Afatinib Impurity 18
CAT No: SZ-A054030
CAS No: 2413212-25-4
Mol.F. : C24H26FN5O3
Mol.Wt. : 451.5
Inv. Status: Custom Synthesis
SZ-A054030
CAS No:2413212-25-4
Mol.F.: C24H26FN5O3 
Mol.Wt.: 451.5
Inv. Status: Custom Synthesis

Afatinib Impurity 19

Picture of Afatinib Impurity 19
CAT No: SZ-A054031
CAS No: 1245555-42-3
Mol.F. : C21H21ClFN5O2
Mol.Wt. : 429.9
Inv. Status: Custom Synthesis
SZ-A054031
CAS No:1245555-42-3
Mol.F.: C21H21ClFN5O2 
Mol.Wt.: 429.9
Inv. Status: Custom Synthesis

Afatinib Impurity 20

Picture of Afatinib Impurity 20
CAT No: SZ-A054032
CAS No: 2085843-51-0
Mol.F. : C22H23ClFN5O2
Mol.Wt. : 443.9
Inv. Status: In Stock
Rel. CAS No : 2085843-52-1 (2HCl salt)
SZ-A054032
CAS No:2085843-51-0
Mol.F.: C22H23ClFN5O2 
Mol.Wt.: 443.9
Inv. Status: In Stock
Rel. CAS No : 2085843-52-1 (2HCl salt)

Afatinib Impurity 21

Picture of Afatinib Impurity 21
CAT No: SZ-A054033
CAS No: 2044709-72-8
Mol.F. : C18H16F2N4O2
Mol.Wt. : 358.4
Inv. Status: Custom Synthesis
SZ-A054033
CAS No:2044709-72-8
Mol.F.: C18H16F2N4O2 
Mol.Wt.: 358.4
Inv. Status: Custom Synthesis

Afatinib Impurity 22

Picture of Afatinib Impurity 22
CAT No: SZ-A054034
CAS No: NA
Mol.F. : C28H29ClFN5O7
Mol.Wt. : 601.1
Inv. Status: Under Synthesis
SZ-A054034
CAS No:NA
Mol.F.: C28H29ClFN5O7
Mol.Wt.: 601.1
Inv. Status: Under Synthesis

Afatinib Dimaleate

Picture of Afatinib Dimaleate
CAT No: SZ-A054035
CAS No: 850140-73-7
Mol.F. : C24H25ClFN5O3 : 2(C4H4O4)
Mol.Wt. : 485.9 : 2(116.1)
Inv. Status: In Stock
Rel. CAS No : 850140-72-6 (free base) ; 1398312-49-6 (HCl salt) ; 1398312-36-1 (Sulfate salt)
SZ-A054035
CAS No:850140-73-7
Mol.F.: C24H25ClFN5O3 : 2(C4H4O4)
Mol.Wt.: 485.9 : 2(116.1)
Inv. Status: In Stock
Rel. CAS No : 850140-72-6 (free base) ; 1398312-49-6 (HCl salt) ; 1398312-36-1 (Sulfate salt)

Afatinib Impurity 23

Picture of Afatinib Impurity 23
CAT No: SZ-A054036
CAS No: 2223677-58-3
Mol.F. : C22H20ClFN4O4
Mol.Wt. : 458.9
Inv. Status: In Stock
SZ-A054036
CAS No:2223677-58-3
Mol.F.: C22H20ClFN4O4
Mol.Wt.: 458.9
Inv. Status: In Stock

Afatinib Sulfonic Acid Analog

Picture of Afatinib Sulfonic Acid Analog
CAT No: SZ-A054037
CAS No: 2283295-16-7
Mol.F. : C24H27ClFN5O6S
Mol.Wt. : 568.0
Inv. Status: Custom Synthesis
SZ-A054037
CAS No:2283295-16-7
Mol.F.: C24H27ClFN5O6S
Mol.Wt.: 568.0
Inv. Status: Custom Synthesis

Afatinib Butoxy Analog

Picture of Afatinib Butoxy Analog
CAT No: SZ-A054039
CAS No: NA
Mol.F. : C24H27ClFN5O2
Mol.Wt. : 472.0
Inv. Status: Custom Synthesis
SZ-A054039
CAS No:NA
Mol.F.: C24H27ClFN5O2
Mol.Wt.: 472.0
Inv. Status: Custom Synthesis

Afatinib Impurity 22

Picture of Afatinib Impurity 22
CAT No: SZ-A054041
CAS No: NA
Mol.F. : C20H18ClFN4O3
Mol.Wt. : 416.8
Inv. Status: Under Synthesis
SZ-A054041
CAS No:NA
Mol.F.: C20H18ClFN4O3
Mol.Wt.: 416.8
Inv. Status: Under Synthesis

Afatinib Impurity 23

Picture of Afatinib Impurity 23
CAT No: SZ-A054042
CAS No: 2475095-50-0
Mol.F. : C14H7ClF2N4O2
Mol.Wt. : 336.7
Inv. Status: Custom Synthesis
SZ-A054042
CAS No:2475095-50-0
Mol.F.: C14H7ClF2N4O2
Mol.Wt.: 336.7
Inv. Status: Custom Synthesis

Afatinib Impurity 24

Picture of Afatinib Impurity 24
CAT No: SZ-A054043
CAS No: 1255078-56-8
Mol.F. : C8H15NO2 : HCl
Mol.Wt. : 157.2 : 36.5
Inv. Status: In Stock
Rel. CAS No : 1086268-91-8 (free base)
SZ-A054043
CAS No:1255078-56-8
Mol.F.: C8H15NO2 : HCl
Mol.Wt.: 157.2 : 36.5
Inv. Status: In Stock
Rel. CAS No : 1086268-91-8 (free base)

Afatinib Impurity 25

Picture of Afatinib Impurity 25
CAT No: SZ-A054044
CAS No: 212776-19-7
Mol.F. : C7H13NO2
Mol.Wt. : 143.2
Inv. Status: In Stock
Rel. CAS No : 1259519-60-2 (HCl salt)
SZ-A054044
CAS No:212776-19-7
Mol.F.: C7H13NO2
Mol.Wt.: 143.2
Inv. Status: In Stock
Rel. CAS No : 1259519-60-2 (HCl salt)

Afatinib Impurity 26

Picture of Afatinib Impurity 26
CAT No: SZ-A054045
CAS No: 314771-88-5
Mol.F. : C18H14ClFN4O4
Mol.Wt. : 404.8
Inv. Status: Custom Synthesis
SZ-A054045
CAS No:314771-88-5
Mol.F.: C18H14ClFN4O4
Mol.Wt.: 404.8
Inv. Status: Custom Synthesis

Afatinib Impurity 27

Picture of Afatinib Impurity 27
CAT No: SZ-A054046
CAS No: 618061-76-0
Mol.F. : C24H27ClFN4O6P
Mol.Wt. : 552.9
Inv. Status: Custom Synthesis
SZ-A054046
CAS No:618061-76-0
Mol.F.: C24H27ClFN4O6P
Mol.Wt.: 552.9
Inv. Status: Custom Synthesis

Afatinib Impurity 28

Picture of Afatinib Impurity 28
CAT No: SZ-A054047
CAS No: NA
Mol.F. : C22H20ClFN4O4
Mol.Wt. : 458.9
Inv. Status: Custom Synthesis
SZ-A054047
CAS No:NA
Mol.F.: C22H20ClFN4O4
Mol.Wt.: 458.9
Inv. Status: Custom Synthesis

Afatinib Impurity 29

Picture of Afatinib Impurity 29
CAT No: SZ-A054048
CAS No: NA
Mol.F. : C22H23ClFN4O6P
Mol.Wt. : 524.9
Inv. Status: Custom Synthesis
SZ-A054048
CAS No:NA
Mol.F.: C22H23ClFN4O6P
Mol.Wt.: 524.9
Inv. Status: Custom Synthesis

Afatinib Impurity 32

Picture of Afatinib Impurity 32
CAT No: SZ-A054051
CAS No: 2323570-72-3
Mol.F. : C24H27ClFN5O4
Mol.Wt. : 504.0
Inv. Status: In Stock
SZ-A054051
CAS No:2323570-72-3
Mol.F.: C24H27ClFN5O4
Mol.Wt.: 504.0
Inv. Status: In Stock

Afatinib Impurity 33

Picture of Afatinib Impurity 33
CAT No: SZ-A054057
CAS No: 162012-69-3
Mol.F. : C8H4FN3O3
Mol.Wt. : 209.1
Inv. Status: Custom Synthesis
SZ-A054057
CAS No:162012-69-3
Mol.F.: C8H4FN3O3
Mol.Wt.: 209.1
Inv. Status: Custom Synthesis

Afatinib Impurity 34

Picture of Afatinib Impurity 34
CAT No: SZ-A054058
CAS No: 16499-57-3
Mol.F. : C8H5FN2O
Mol.Wt. : 164.1
Inv. Status: Custom Synthesis
SZ-A054058
CAS No:16499-57-3
Mol.F.: C8H5FN2O
Mol.Wt.: 164.1
Inv. Status: Custom Synthesis

Afatinib Impurity 35

Picture of Afatinib Impurity 35
CAT No: SZ-A054059
CAS No: 2226537-61-5
Mol.F. : C14H7F3N4O2
Mol.Wt. : 320.2
Inv. Status: Custom Synthesis
SZ-A054059
CAS No:2226537-61-5
Mol.F.: C14H7F3N4O2
Mol.Wt.: 320.2
Inv. Status: Custom Synthesis

Afatinib Impurity 36

Picture of Afatinib Impurity 36
CAT No: SZ-A054060
CAS No: 2044709-79-5
Mol.F. : C18H16Cl2N4O2
Mol.Wt. : 391.3
Inv. Status: Custom Synthesis
SZ-A054060
CAS No:2044709-79-5
Mol.F.: C18H16Cl2N4O2
Mol.Wt.: 391.3
Inv. Status: Custom Synthesis

Stable Isotopes and Metabolites

Afatinib D4

Picture of Afatinib D4
CAT No: SZ-A054D01
CAS No: NA
Mol.F. : C24H21D4ClFN5O3
Mol.Wt. : 490.0
Inv. Status: Custom Synthesis
Rel. CAS No : 850140-72-6(Unlabeled)
SZ-A054D01
CAS No:NA
Mol.F.: C24H21D4ClFN5O3
Mol.Wt.: 490.0
Inv. Status: Custom Synthesis
Rel. CAS No : 850140-72-6(Unlabeled)

Afatinib D6

Picture of Afatinib D6
CAT No: SZ-A054D02
CAS No: 1313874-96-2
Mol.F. : C24H19D6ClFN5O3
Mol.Wt. : 492.0
Inv. Status: Custom Synthesis
SZ-A054D02
CAS No:1313874-96-2
Mol.F.: C24H19D6ClFN5O3
Mol.Wt.: 492.0
Inv. Status: Custom Synthesis

Possible Nitroso Standards

Afatinib Nitroso Impurity 1

Picture of Afatinib Nitroso Impurity 1
CAT No: SZ-A054040
CAS No: NA
Mol.F. : C24H24ClFN6O4
Mol.Wt. : 514.9
Inv. Status: Under Synthesis
SZ-A054040
CAS No:NA
Mol.F.: C24H24ClFN6O4
Mol.Wt.: 514.9
Inv. Status: Under Synthesis