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Valsartan Sacubitril

SZ目录编号 SZ-S020038
CAS 号 936623-90-4
分子式 C24H29NO5 : C24H29N5O3 : 3Na : 5/2(H20)
分子量 411.5 : 435.5 : 3(23.0) : 5/2(18.0)
投资状态 Under Synthesis


化学名称: N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-N-pentanoyl-L-valine compound with 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid (1:1) trisodium Hemipentahydrate

微笑: C[C@@H](C(OCC)=O)C[C@H](NC(CCC(O)=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1.O=C(CCCC)N([C@H](C(O)=O)C(C)C)CC3=CC=C(C4=C(C5=NN=NN5)C=CC=C4)C=C3.[5/2H2O].[3Na]

印地语: InChI=1S/C17H18ClN3O3.C2HF3O2/c18-13-8-14-11(7-15(13)20-5-3-19-4-6-20)16(22)12(17(23)24)9-21(14)10-1-2-10;3-2(4,5)1(6)7/h7-10,19H,1-6H2,(H,23,24);(H,6,7)

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou,  Liang Zou,  Lili Sun,  Hui Zhang,  Wenkai Hui and  Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053
 
Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645
 
Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)
 
Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107