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Sacubitril N-Acetyl Impurity

SZ目录编号 SZ-S020044
分子式 C22H27NO3
分子量 353.5
投资状态 In Stock

化学名称: Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-acetamido-2-methylpentanoate

微笑: CC(N[C@](C[C@@]([H])(C)C(OCC)=O)([H])CC1=CC=C(C=C1)C2=CC=CC=C2)=O

印地语: InChI=1S/C16H19Br2NO3/c1-2-12-8-19(9-13(12)14(20)15(17)18)16(21)22-10-11-6-4-3-5-7-11/h3-7,12-13,15H,2,8-10H2,1H3/t12-,13+/m1/s1

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou,  Liang Zou,  Lili Sun,  Hui Zhang,  Wenkai Hui and  Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053
Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645
Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)
Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107