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Sacubitril Impurity 41

SZ目录编号 SZ-S020053
CAS 号 NA
分子式 C20H25NO2 : HCl
分子量 311.4 : 36.5
投资状态 Custom Synthesis
Rel. CAS No 1995860-03-1 (free base)


化学名称: Ethyl (2S,4R)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride

微笑: O=C(OCC)[C@@H](C)C[C@@H](N)CC1=CC=C(C2=CC=CC=C2)C=C1.Cl

印地语: InChI=1S/C6H5ClN4O4S2/c7-3-1-4-6(2-5(3)16(8,12)13)17(14,15)11-10-9-4/h1-2H,(H,9,11)(H2,8,12,13)

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou,  Liang Zou,  Lili Sun,  Hui Zhang,  Wenkai Hui and  Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053
 
Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645
 
Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)
 
Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107