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Sacubitril Impurity 40

SZ目录编号 SZ-S020052
CAS 号 2514965-95-6
分子式 C25H31NO5
分子量 425.5
投资状态 Custom Synthesis


化学名称: 4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-isopropoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid

微笑: O=C(CCC(O)=O)N[C@@H](C[C@@H](C)C(OC(C)C)=O)CC(C=C1)=CC=C1C2=CC=CC=C2

印地语: InChI=1S/C10H15NO3.ClH/c1-8-9(4-5-11-10(8)12)14-7-3-6-13-2;/h4-5H,3,6-7H2,1-2H3,(H,11,12);1H

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou,  Liang Zou,  Lili Sun,  Hui Zhang,  Wenkai Hui and  Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053
 
Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645
 
Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)
 
Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107