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Sacubitril Impurity 34

SZ目录编号 SZ-S020042
CAS 号 1660147-07-8
分子式 C17H19NO2
分子量 269.3
投资状态 Custom Synthesis


化学名称: (R)-N-(1-([1,1'-Biphenyl]-4-yl)-3-hydroxypropan-2-yl)acetamide

微笑: OC[C@H](NC(C)=O)CC1=CC=C(C2=CC=CC=C2)C=C1

印地语: InChI=1S/C22H27NO4/c1-16(24)26-15-20(23-21(25)27-22(2,3)4)14-17-10-12-19(13-11-17)18-8-6-5-7-9-18/h5-13,20H,14-15H2,1-4H3,(H,23,25)/t20-/m1/s1

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou,  Liang Zou,  Lili Sun,  Hui Zhang,  Wenkai Hui and  Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053
 
Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645
 
Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)
 
Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107