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Sacubitril Impurity 26

SZ目录编号 SZ-S020032
分子式 C23H25NO5
分子量 395.5
投资状态 Custom Synthesis

化学名称: (E)-4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobut-2-enoic acid

微笑: COC([C@H](C)C[C@H](NC(/C=C/C(O)=O)=O)CC1=CC=C(C=C1)C2=CC=CC=C2)=O

印地语: InChI=1S/C16H26O4/c1-9-5-7-13-11(3)14(18-4)20-15-16(13,17)12(9)8-6-10(2)19-15/h6,9,11-15,17H,5,7-8H2,1-4H3/t9-,11-,12+,13+,14+,15+,16-/m1/s1

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou,  Liang Zou,  Lili Sun,  Hui Zhang,  Wenkai Hui and  Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053
Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645
Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)
Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107