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Posaconazole Impurity 43

SZ目录编号 SZ-P022063
CAS 号 161532-56-5
分子式 C32H32F2N8O3
分子量 614.7
投资状态 Custom Synthesis


化学名称: D-​threo-​Pentitol, 2,​5-​anhydro-​1,​3,​4-​trideoxy-​2-​C-​(2,​4-​difluorophenyl)​-​4-​[[4-​[4-​[4-​(1,​5-​dihydro-​5-​oxo-​4H-​1,​2,​4-​triazol-​4-​yl)​phenyl]​-​1-​piperazinyl]​phenoxy]​methyl]​-​1-​(1H-​1,​2,​4-​triazol-​1-​yl)​-; 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-(1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl)phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol

微笑: O=C(NN=C1)N1C2=CC=C(N3CCN(C4=CC=C(OC[C@@H]5CO[C@@](CN6N=CN=C6)(C7=C(F)C=C(F)C=C7)C5)C=C4)CC3)C=C2

印地语: InChI=1S/C37H42F2N8O5.C2HF3O2/c1-3-35(26(2)48)46-36(49)45(25-42-46)30-7-5-29(6-8-30)43-14-16-47(50,17-15-43)31-9-11-32(12-10-31)51-20-27-19-37(52-21-27,22-44-24-40-23-41-44)33-13-4-28(38)18-34(33)39;3-2(4,5)1(6)7/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3;(H,6,7)/t26-,27+,35-,37-;/m0./s1

Influence of cyclodextrin on posaconazole stability, release and activity: Improve the utility of the drug
By Santana, Ana Cristina Sousa Gramoza Vilarinho; Nadvorny, Daniela; da Rocha Passos, Taisa Daiany; de La Roca Soares, Monica Felts; Soares-Sobrinho, Jose Lamartine
From Journal of Drug Delivery Science and Technology (2019), 53, 101153
 
Stability-​indicating HPLC method development and structural elucidation of novel degradation products in posaconazole injection by LC-​TOF​/MS, LC-​MS​/MS and NMR
By Yang, Yidi; Zhu, Xi; Zhang, Fei; Li, Wei; Wu, Ying; Ding, Li
From Journal of Pharmaceutical and Biomedical Analysis (2016), 125, 165-177
 
Stability indicating HPLC method for the quantification of posaconazole and its related substances
By Govind, Sampath Kumar Reddy; Nagaraju, Ch. V. S.; Rajan, S. T.; Eshwaraiah, S.; Kishore, M.; Rakesh, M.; Chakravarthy, I. E.
From Pharma Chemica (2014), 6(1), 486-494, 9 pp..