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Ledipasvir Impurity-7

SZ目录编号 SZ-L010017
分子式 C18H23N3O2
分子量 313.4
投资状态 Custom Synthesis

化学名称: Tert-butyl (1R,3S,4S)-3-(1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate

微笑: CC(C)(C)OC(N1[C@H](C2=NC3=CC=CC=C3N2)[C@@]4([H])CC[C@]1([H])C4)=O

印地语: InChI=1S/C49H54F2N8O6/c1-24(2)39(56-46(62)64-5)44(60)58-23-48(15-16-48)21-38(58)42-52-22-37(55-42)28-9-13-32-31-12-8-26(18-33(31)49(50,51)34(32)19-28)27-10-14-35-36(20-27)54-43(53-35)41-29-7-11-30(17-29)59(41)45(61)40(25(3)4)57-47(63)65-6/h8-10,12-14,18-20,22,24-25,29-30,38-41H,7,11,15-17,21,23H2,1-6H3,(H,52,55)(H,53,54)(H,56,62)(H,57,63)/t29-,30-,38+,39+,40+,41+/m1/s1

Insights into the Dissolution Behavior of Ledipasvir-Copovidone Amorphous Solid Dispersions: Role of Drug Loading and Intermolecular Interactions
Chailu Que, Xiaochun Lou, Dmitry Y. Zemlyanov, Huaping Mo, Anura S. Indulkar, Yi Gao, Geoff G.Z. Zhang, and Lynne S. Taylor
Mol. Pharmaceutics 2019, 16, 12, 5054–5067
A green stability-indicating RP-HPLC-UV method using factorial design for determination of ribavirin, sofosbuvir and ledipasvir: Application to average content, acid degradation kinetics and in vitro drug interactions study
Hanan I.EL-ShorbagyacFawziElsebaeiaSherin F.HammadbAmina M.El-Brashy
Microchemical Journal Volume 158, November 2020, 105251
Simultaneous chromatographic analysis of Sofosbuvir/Ledipasvir in their combined dosage form: an application to green analytical chemistry
Ahmed Hemdan & Maya S. Eissa
Journal of Analytical Science and Technology volume 10, Article number: 39 (2019)
Chemometrically Assisted RP-HPLC and Spectroscopic Method Development for Simultaneous Multi-Component Analysis of Ledipasvir and Sofosbuvir in Pure and Pharmaceutical Formulation
Roma N Trivedi1* , Jinal N Tandel2 , Rashmika C Patel2 , Samir K Shah2
Der Pharmacia Lettre, 2018, 10 [3]: 62-75