化学名称: (2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-((5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)morpholine 4-oxide
微笑: O=[N]([C@](C(C=C1)=CC=C1F)([H])[C@H]2O[C@@H](C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)(CCO2)CC(N4)=NNC4=O
印地语: InChI=1S/C23H21F7N4O3/c1-12(14-7-15(22(25,26)27)10-16(8-14)23(28,29)30)37-20-19(13-3-2-4-17(24)9-13)34(5-6-36-20)11-18-31-21(35)33-32-18/h2-4,7-10,12,19-20H,5-6,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1
Application of analytical quality by design principles for the determination of alkyl p-toluenesulfonates impurities in Aprepitant by HPLC. Validation using total-error concept
Constantinos K. Zacharis, Elli Vastardi
Journal of Pharmaceutical and Biomedical Analysis Volume 150, 20 February 2018, Pages 152-161
Characterization and Quantitation of Aprepitant Drug Substance Polymorphs by Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy
Roy Helmy,* George X. Zhou, Yadan W. Chen, Louis Crocker, Tao Wang, Robert M. Wenslow, Jr., and Anant Vailaya*
Anal. Chem. 2003, 75, 605-611
Development and Optimization of Liquid Chromatography Analytical Methods by Using AQbD Principles: Overview and Recent Advances
Tim Tome,†,Nina Ž igart, Zdenko Č asar,, and AlešObreza
Org. Process Res. Dev. 2019, 23, 1784−1802