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(2R,4S)-Sacubitril

SZ目录编号 SZ-S020030
CAS 号 761373-05-1
分子式 C24H29NO5
分子量 411.5
投资状态 In Stock


化学名称: [R-(R*,S*)]-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1’-biphenyl]-4-pentanoic Acid α-Ethyl Ester ; (αS,γR)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1’-biphenyl]-4-pentanoic Acid 4-Ethyl Ester ; Sacubitril Enantiomer

异名: Sacubitril-(2S,4R)-Isomer

微笑: O=C(OCC)[C@@H](C)C[C@@H](NC(CCC(O)=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1

印地语: InChI=1S/C16H19NO5/c1-3-21-15(19)13(10-9-12-7-5-4-6-8-12)17-11(2)14(18)22-16(17)20/h4-8,11,13H,3,9-10H2,1-2H3/t11-,13-/m1/s1

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou,  Liang Zou,  Lili Sun,  Hui Zhang,  Wenkai Hui and  Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053
 
Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645
 
Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)
 
Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107