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Sacubitril Impurity 37

N° de SZ CAT SZ-S020048
Número CAS 1573000-36-8
Mol.F. C19H18ClNO2
Peso Molecular 327.8
Status de Fatura Custom Synthesis

Nome Químico: (R)-1-(1-([1,1'-Biphenyl]-4-yl)-3-chloropropan-2-yl)pyrrolidine-2,5-dione

Sorrisos: ClC[C@H](N(C1=O)C(CC1)=O)CC2=CC=C(C3=CC=CC=C3)C=C2

Inchi: InChI=1S/C24H27N3O6/c1-2-33-24(31)21(14-12-17-8-4-3-5-9-17)27(25-32)20-15-13-18-10-6-7-11-19(18)26(23(20)30)16-22(28)29/h3-11,20-21H,2,12-16H2,1H3,(H,28,29)/t20-,21-/m0/s1

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou,  Liang Zou,  Lili Sun,  Hui Zhang,  Wenkai Hui and  Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053
Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645
Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)
Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107